post oprative pain managment

references: 1. miller rd. miller’s anesthesia. 7th ed. philadelphia: churchill livingstone 2010 2758-9. 2. macintyre pe, schug sa, scott da, visser ej, walker sm. apm:se working group of the australian and new zealand college of anaesthetists and faculty of pain medicine. acute pain management: scientific evidence. 3rd ed. melbourne: anzca & fpm 2010 9-12. 3. buvanendran a. chronic postsurgical pain: are we closer to understanding the puzzle? anesth analg 2012115(2):231-2 4. ramaswamy s, wilson ja, colvin l. non-opioid-based adjuvant analgesia in perioperative care. bja: ceaccp 201313(5):152-7 5. clarke h, bonin rp, orser ba, englesakis m, wijeysundera dn, katz j. the prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. anesth analg 2012 115(2):428-442. 6. tiippana em, hamunen k, kontinen vk, kalso e. do surgical patients benefit from perioperative gabapentin/pregabalin? a systematic review of efficacy and safety. anesth analg 2007 104(6):1545–56 . 7. schmidt pc, ruchelli g, mackey sc, carroll ir. perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain. anesthesiology 2013 119(5):1215-21 . 8. bauer cs, rahman w, tran-van-minh a, lujan r, dickenson ah, dolphin ac. the anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminals in vivo. biochem. soc. trans 2010 38(2):525–528 . 9. sills gj. the mechanisms of action of gabapentin and pregabalin. curr. opin. pharmacol 20066(1):108–113 . 10. weinbroum aa. non-opioid iv adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoids. pharmacol. res 2012 65(4):411-29.